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{“main-title”:{“component”:”hc_title”,”id”:”main-title”,”subtitle”:”In vitro ADME and Pharmacokinetics “,”title_content”:{“component”:”hc_title_image”,”id”:”title-image”,”image”:”https://www.iontox.com/wp-content/uploads/2017/09/shutterstock_639684970-1024×650.jpg|1143|1800|3190″,”full_screen”:false,”full_screen_height”:””,”parallax”:false,”bleed”:””,”ken_burn”:””,”overlay”:”transparent-dark”,”breadcrumbs”:false,”white”:true},”title”:”ADME-PK”},”section_5ZtkF”:{“component”:”hc_section”,”id”:”section_5ZtkF”,”section_width”:””,”animation”:””,”animation_time”:””,”timeline_animation”:””,”timeline_delay”:””,”timeline_order”:””,”vertical_row”:””,”box_middle”:””,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”section_content”:[{“component”:”hc_column”,”id”:”column_BO0xM”,”column_width”:”col-md-12″,”animation”:””,”animation_time”:””,”timeline_animation”:””,”timeline_delay”:””,”timeline_order”:””,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”main_content”:[{“component”:”hc_space”,”id”:”TN6F1″,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”size”:”l”,”height”:””},{“component”:”hc_title_tag”,”id”:”0WG46″,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”text”:”ADME-PK Assays”,”tag”:”h2″},{“component”:”hc_space”,”id”:”HeW1Z”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”size”:”l”,”height”:””},{“component”:”hc_text_block”,”id”:”tUqmn”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”content”:”For over 50 years, pharmacokinetics (PK) has been described using the 4 letter acronym ADME, or absorption, distribution, metabolism, and excretion.  As the cost of bringing a drug to market increases and the potential for marketed drug withdrawals due to unforeseen ADME issues climb, it is crucial to fully characterize your drug candidates as early as possible.  ADME/PK screening in the hit-to-lead and lead optimization phases can help reduce failure rates later on by offering accurate information on ADME, potential drug-drug interactions (DDIs) and potential unforeseen toxicities.”},{“component”:”hc_space”,”id”:”5ZtkF”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”size”:”l”,”height”:””},{“component”:”hc_text_block”,”id”:”0a6Jr”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”content”:”In vitro ADME-PK services”},{“component”:”hc_icon_list”,”id”:”tYEoj”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”wVXFH”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” Caco-2 Permeability“}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””},{“component”:”hc_icon_list”,”id”:”r08aK”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”A6aTm”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” Metabolic Stability“}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””},{“component”:”hc_icon_list”,”id”:”y5Olq”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”9KTUV”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” CYP Induction “}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””},{“component”:”hc_icon_list”,”id”:”y9q74″,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”vAglY”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” CYP Inhibition “}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””},{“component”:”hc_icon_list”,”id”:”hS7zp”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”ukPIF”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” Plasma Protein Binding“}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””},{“component”:”hc_icon_list”,”id”:”VzyEE”,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”rows”:[{“component”:”repeater_item”,”id”:”F4bkC”,”icon”:”fa fa-long-arrow-right”,”icon_style”:””,”icon_image”:””,”text”:” Blood Partitioning“}],”direction”:””,”alignment”:”text-left”,”icon_position”:””,”text_size”:””,”icon_size”:””}]},{“component”:”hc_column”,”id”:”column_dPcfs”,”column_width”:”col-md-12″,”animation”:””,”animation_time”:””,”timeline_animation”:””,”timeline_delay”:””,”timeline_order”:””,”css_classes”:””,”custom_css_classes”:””,”custom_css_styles”:””,”main_content”:[]}],”section_settings”:””},”scripts”:{},”css”:{},”css_page”:””,”template_setting”:{“settings”:{“id”:”settings”}},”template_setting_top”:{},”page_setting”:{“settings”:[“lock-mode-off”]}}