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Dynamic Multiple Organ Testing

Understand drug and chemical movement 

Dynamic Multiple Organ Testing provides a novel way for scientists to evaluate drug or chemical movement from one organ to another, study Pharmacokinetic/Pharmacodynamic effects, and understand communication between organ compartments via a semi-permeable membrane.  In this meso-scale model, there is no net change in fluid between compartments and critical information on compound absorption, metabolism, and toxicity can be monitored.

How It Works 

IONTOX’s patented Human Dynamic Multiple Organ Plate (HuDMOPTM) used for the company’s Dynamic Multiple Organ Testing was designed to understand how a new drug candidate will impact systemic organ function in human beings in vitro. This next generation in vitro test incorporates a multiple organ platform with simulated blood flow necessary for evaluating systemic toxicity. In this system a simple (two organ) may be chosen or more complex multiple organ models can be developed.

The figure to the right, represents a physiologically based pharmacokinetic model for nicotine in a lung-liver setup. The three display the simulated movement of nicotine in the lung basolateral compartment, simulated blood, and delivery to the liver compartment (solid red line).  The data points represent the actual collected data.

Where to begin 

To learn more about IONTOX’s multiple organ testing in vitro, read more about the development of the HuDMOPTM. Build a multiple organ study by clicking one of the buttons below and receive a quote within the next 24 to 48 hours. For more more information on Dynamic Multiple Organ Testing call 269.372.3395 to talk with an IONTOX scientist, or email us at info@iontox.com.