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Through IONTOX’s extensive R&D efforts, the company has developed a novel Dynamic Multi-Organ Plate (DMOP) with simulated blood flow. This plate is now available to our clients as a service performed within IONTOX laboratories. Studies to date include monitoring the movement of drugs from an intestinal chamber to a liver chamber and from a lung chamber to a liver chamber. The pharmacokinetics and pharmacodynamics of drugs and chemicals can be monitored. Metabolism at barrier membranes can be determined. Important parameters, such as organ size and blood flow, can be controlled in this system. The simulated blood flow uses dialysis membrane tubing. Dialysis membrane tubing allows analytes and small diffusible molecules to move from simulated blood to tissue and from tissue back into the fluidics system. It is important to note that the media in which each different tissue type is cultured does not change or exchange with other organ chambers. The simulated blood system is completely isolated with the only communication between blood and tissue being by dialysis in the tissue chamber. Tubing connecting tissue compartments is not permeable. There is no net gain or loss of fluids only osmotically active molecules. This movement can be modeled and the models used to predict a test compound’s impact in humans. The Dynamic Multi-Organ Plate provides an innovative meso-scale system for assessing systemic toxicity and effects in multiple organs.

DMOP will greatly enhance new drug and chemical safety testing by:

    Integrating key organ systems that provide better information on systemic toxicity.
    Providing for key routes of exposure, such as oral and inhalation.
    Taking into account important events, such as gut absorption, metabolism, time, multiple organ exposures, and compound effects on multiple tissues.
    Offering pharmacokinetic models describing movement between organ compartments on the plate.
    Demonstrating more accurate in vitro to in vivo extrapolations.

Products in Development

Dynamic Multiple Organ Plate

The Dynamic Multiorgan Plate is an integrated meso-scale human multiorgan culture plate that can be used for predicting systemic toxicity.

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Inhalation Chamber

An extension of the Dynamic Multiorgan Plate, the mini-inhalation chamber allows for the treatment of human lung tissue in the Plate by smoke, vapor or aerosol.

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Pharmacokinetic Model

The Model will translate data generated in the Dynamic Multiorgan Plate to actual human drug kinetics to better predict drug impact in humans.

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