Through IONTOX’s extensive R&D efforts, the company has developed a novel Dynamic Multi-Organ Plate (DMOP) with simulated blood flow. This plate is now available to our clients as a service performed within IONTOX laboratories. Studies to date include monitoring the movement of drugs from an intestinal chamber to a liver chamber and from a lung chamber to a liver chamber. The pharmacokinetics and pharmacodynamics of drugs and chemicals can be monitored. Metabolism at barrier membranes can be determined. Important parameters, such as organ size and blood flow, can be controlled in this system. The simulated blood flow uses dialysis membrane tubing. Dialysis membrane tubing allows analytes and small diffusible molecules to move from simulated blood to tissue and from tissue back into the fluidics system. It is important to note that the media in which each different tissue type is cultured does not change or exchange with other organ chambers. The simulated blood system is completely isolated with the only communication between blood and tissue being by dialysis in the tissue chamber. Tubing connecting tissue compartments is not permeable. There is no net gain or loss of fluids only osmotically active molecules. This movement can be modeled and the models used to predict a test compound’s impact in humans. The Dynamic Multi-Organ Plate provides an innovative meso-scale system for assessing systemic toxicity and effects in multiple organs.
DMOP will greatly enhance new drug and chemical safety testing by: