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Organ Specific Toxicity

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ORGAN SPECIFIC TOXICITY

Organ Toxicity

 

IONTOX offers a wide range of organ-specific toxicity test systems for clients who are gathering information on how a compound may impact organ health.

Many of the in vitro methods used industry-wide were pioneered by IONTOX founder Dr. James McKim 15 years ago. IONTOX continues this trend of innovation by finding and developing the latest in vitro toxicity testing and putting these to work for your business. For any questions or to inquire about a specific service or offering email us at info@iontox.com, request a quote via our website, or call 269-373-3395.

Skin Sensitization & Toxicity  

  • Cytotoxicity
  • Dermal Corrosion
  • Dermal Irritation
  • ET-50(Potency)

 

Over the past 15 years, approaches to dermal toxicity screening have significantly evolved.

Human skin cell and tissue models have improved, and we now have more sensitive markers of toxicity and new in vitro strategies for assessing adverse effects. Pharmaceutical, chemical, and cosmetic companies who design products for topical use not only have to ensure the safety of a product, but they are also often required to do these safety studies without the use of animals. This has led to the development of new in vitro models for evaluating dermal exposure to chemicals.  These models have been shown to be highly predictive of actual effects on human skin.

To learn more, click Skin Toxicity & Sensitization in vitro.

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    MatTek EpiDerm™ used for all 3D tissue models
    HaCaT Cells
    Other cell models available upon request

 

 

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Ocular Sensitization & Toxicity

  • Ocular Irritation
  • ET 50 (Potency)

Predict the potential of your test compound or xenobiotic to cause ocular irritation using our Eye Irritation Test (EIT).

Historically, ocular irritation was performed on rabbits using the Draize Eye Test.2 However, three-dimensional human corneal tissue equivalents have been developed and validated as replacements for the Draize test. These 3D tissues are nonkeratinized corneal epithelia grown from normal human keratinocytes and are very similar to the native human cornea, both metabolically and morphologically. In addition, the apical surface is in direct contact with the air (tissue is fed basally) allowing for testing of almost all types of materials, such as gels, creams, liquids, and powders, regardless of aqueous solubility.

 

To learn more about ocular Irritation in vitro see our page on ocular irritation

In vitro models 

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    MatTek EpiOcular™ used for all 3D ocular models
    Other models available upon request

 

 

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Liver Toxicity

  • Cytotoxicity
    Biliary Clearance
    IDILI Liability

 

Companies with new compounds seeking to identify and understand potential adverse effects from chemical exposure must understand liver toxicity as a first step. The liver regulates several important processes necessary for survival and is often the first organ to be exposed to a test agent. Therefore, understanding compound effects on the liver is a critical first step.

In addition to standard liver models and screens, IONTOX has attained an exclusive license to screen for IDILI Liability in vitro.

 

Critical Functions of The Liver

    Carbohydrate metabolism
    Glucose regulation
    Synthesis, storage, processing of fats
    Metabolism of xenobiotics

In vitro models 

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    HepG2 (Human)
    H4IIE
    Hepatocytes in Sandwich Culture for understanding Biliary Clearance
    Other cell models available upon request

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Lung Specific Toxicity

  • Cytotoxicity
  • Inflammation
  • Metabolism

Pharmaceutical, tobacco, nutraceutical, cosmetic, and agrochemical companies often need to identify hazards associated with the inhalation of products.

Many chemical agents gain entry to the body via inhalation and therefore assessment of normal lung function is essential for understanding chemical safety.

Critical Functions of Lungs

    Oxygen uptake and CO2 elimination
    Metabolism
    Particulate filter

In vitro models 

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    Epithelix MucilAir™
    Other Models Available Upon Request

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Kidney Toxicity

    Cytotoxicity
    Drug Drug Interaction (DDI)

Pharmaceutical, chemical, and cosmetic companies are responsible for ensuring that their products are safe for human use and in the event of misuse, that any adverse systemic effects are known.

An important challenge for these industries is the immediate need to reduce or replace animal testing. This means that in vitro alternatives must be found to test new drug candidates, chemical ingredients, or finished products.

In the past, companies could evaluate the safety of new drugs, chemicals, or finished products in animal studies. Although some animal studies are still done on a routine basis, there is real regulatory, consumer, and corporate pressure to reduce, refine, and even replace animal toxicity testing.

In vitro models 

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    HK-2
    ciPTEC IONTOX exclusive model
    Other Models available upon request

 

 

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Intestine Toxicity

    Cytotoxicity
    Compound permeability/Absorption
    Metabolism
    Inflammation

Pharmaceutical, nutraceutical, food additive, and chemical companies need to know how their compounds affect intestinal cell health.

Chemicals entering the intestinal tract can affect the intestinal epithelium. Compounds that enter the body orally enter the gastrointestinal tract (GIT). The GIT is a complex system that facilitates the digestion and absorption of food-derived fats, carbohydrates, and proteins. The primary site of enzymatic breakdown and absorption is the upper portion of the small intestine (duodenum). Chemicals that enter the intestine via ingestion of medicines or food products are absorbed into the portal circulation and carried to the liver. During the absorption process, compounds can undergo metabolism by Cytochrome P450 enzymes in the intestinal epithelium. Exogenous compounds can also induce inflammatory responses in the intestine or cause direct toxicity.

Critical functions of the gastrointestinal tract

    Break down food for use; Propulsion
    Mechanical digestion; Chemical digestion
    Nutrient absorption; Waste production

In vitro models 

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    MatTek EpiIntestinal™
    Caco-2
    Other models available upon request

 

 

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