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Organ Specific Toxicity

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Organ Specific Toxicity
Understand Organ Specific Toxicity Prior to Entering Clinical Trials
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Available Organ Specific Screens


Organ specific cytotoxicity test systems are for clients who are gathering initial information on how a compound may impact organ health. Knowing how test compounds interact with a simple one compartment system is necessary before more complex models can be used.

A single organ is used to identify mechanisms of toxicity, screen a large number of compounds for efficacy or toxicity relative to reference compounds and then use these data to rank order compounds.

Single organ testing is used to identify adverse outcome pathways and targets of toxicity critical to understanding overall chemical hazard and for performing risk assessment.

Many of the in vitro methods used industry wide were pioneered by IONTOX founder Dr. James Mckim 15 years ago. IONTOX continues this trend of innovation by, finding and developing the latest in vitro toxicity testing and putting them to work for your business.


Skin Screens Available 

  • Cytotoxicity
  • Dermal Corrosion
  • Dermal Irration
  • ET-50(Potency)


Over the past 15 years approaches to dermal toxicity screening have significantly evolved.
 Human skin cell and tissue models have improved, we now have more sensitive markers of toxicity, and new in vitro assays for assessing adverse effects.  Pharmaceutical, chemical, and cosmetic companies who design products for topical use, not only have to understand if a product is safe, but they are often required to do these safety studies without the use of animals. This has led to the development of new in vitro models for evaluating dermal exposure to chemicals.  These models have been shown to be highly predictive of actual effects in human skin.
Click here to learn more about Skin Toxicity & Sensitization in vitro

 Request A Quote For Skin Toxicity or Sensitization In Vitro 
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    MatTek EpiDerm™ used for all 3D tissue models 
    HaCaT Cells
    Other cell models available upon request


Ocular Screens Available

  • Ocular Irritation
  • ET 50 (Potency)

Predict the potential of your test compound or xenobiotic to cause ocular irritation using our Eye Irritation Test (EIT). 

Historically, ocular irritation was performed on rabbits using the Draize Eye Test.2  However, three-dimensional human corneal tissue equivalents have been developed and validated as replacements for the Draize test.  These 3D tissues are nonkeratinized, corneal epithelia grown from normal human keratinocytes and are extremely similar to native human cornea, both metabolically and morphologically.  In addition, the apical surface is direct contact with the air (tissue is fed basally) allowing for testing of almost all types materials, such as gels, creams liquids, and powders, regardless of aqueous solubility.

 Request A Quote For Ocular Irritation In Vitro 
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    MatTek EpiOcular™ used for all 3D ocular models 


Liver Screens Available 

  • Cytotoxicity
    Biliary Clearance
    IDILI Liability

Companies with new compounds seeking to identify and understand potential adverse effects from chemical exposure must understand liver toxicity as a first step.

The liver regulates several important processes necessary for survival and is often the first organ to be exposed to a test agent. Therefore, understanding compound effects on liver is a critical first step.

In addition to standard liver models and screens IONTOX has attained an exclusive license to screen for IDILI Liability in vitro. 

Critical Functions of The Liver

    Carbohydrate metabolism
    Glucose regulation
    Synthesis, storage, processing of fats
    Metabolism of xenobiotics
 Request A Quote For Hepatotoxicity In Vitro 
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  • HepG2 (Human)
  • H4IIE
  • Hepatocytes in Sandwich Culture for understanding Biliary Clearance
  • Other cell models available upon request


Lung Screens Available 

  • Cytotoxicity
  • Inflammation
  • Metabolism
  • Membrane damage
    Oxidative stress

  • Mitochondrial function
  • Apoptosis

Pharmaceutical, tobacco, nutraceutical, cosmetic, and agro-chemical companies often need to identify hazards associated with inhalation of products.

Many chemical agents gain entry to the body via inhalation and therefore assessment of normal lung function is essential for understanding chemical safety.

Critical Functions of Lung

  • Oxygen uptake and COelimination
  • Metabolism
  • Particulate filter
 Request A Quote For Inhalation Toxicity
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    Epithelix MucilAir™
    Other Models Available Upon Request


Kidney Screens Available 

    Drug Drug Interaction (DDI)

Pharmaceutical, chemical, and cosmetic companies are responsible for knowing that their products are safe for human use and in the event of misuse that any adverse systemic effects are known.

An important challenge for these industries is the immediate need to reduce or replace animal testing. This means that in vitro alternatives must be found to test new drug candidates, chemical ingredients, or finished products.

In the past, companies could evaluate the safety of new drugs, chemicals, or finished products in animal studies. Although, some animal studies are still done on a routine basis there is real regulatory, consumer, and corporate pressure to reduce, refine, and even replace animal toxicity testing.

 Request A Quote For Renal Toxicity
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  • ciPTEC IONTOX exclusive model 
  • Other Models available upon request


Intestine Screens Available

    Compound permeability/Absorption

Pharmaceutical, nutraceutical, food additive, and chemical companies need to know how their compounds affect the intestinal cell health. Chemicals entering the intestinal tract can affect the intestinal epithelium.

Compounds that enter the body by the oral route, enter the gastrointestinal tract (GIT). The GIT is a complex system that facilitates the digestion and absorption of food derived fats, carbohydrates, and proteins. The primary site of enzymatic breakdown and absorption is the upper portion of the small intestine (duodenum). Chemicals that enter the intestine via ingestion of medicines or food products are absorbed into the portal circulation and carried to the liver. During the absorption process compounds can undergo metabolism by Cytochrome P450 enzymes in the intestinal epithelium. Exogenous compounds can also induce inflammatory responses in the intestine or cause direct toxicity.

Critical functions of the gastrointestinal tract

    Break down food for use; Propulsion
    Mechanical digestion; Chemical digestion
    Nutrient absorption; Waste production
 Request A Quote For Intestinal Toxicity
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    MatTek EpiIntestinal™
    Other models available upon request