Human Dynamic multiple organ testing
An in vitro system for understanding systemic toxicity. In the past toxicologist have relied heavily on animal or human subjects to study the interplay between chemical movement, blood flow, and organ health. However, toxicity testing in the 21st century requires a new system to meet the needs of the rapidly changing drug, chemical, cosmetic, tobacco, markets, and personal care industries.
Single organ acute toxicity testing provides only part of the chemical toxicity story in vitro. The Interaction between key organ systems (e.g. intestine-to-liver) is an essential component to understanding the pharmacokinetics/pharmacodynamics of test chemicals.
IONTOX has found through working with collaborators in the pharmaceutical, chemical, cosmetics, and tobacco industries that there is a need for a multiple organ test system, with a simulated blood system, not just a fluidics system that provides mechanical shear forces. The system should be flexible with regard to the experimental design needs of the client. The ability to study two, three or four organ systems should be possible. Finally, the system should allow the use of cell or tissue models that are well characterized so that the data obtained is easily understood.