HuDMOP® stands for Human Dynamic Multi-Organ Plate. This test uses cultured human tissues representative of specific organs that are connected to one another via a simulated blood system. Each organ compartment contains growth media optimal for that particular tissue or cell type.
There is no net exchange of fluid between the compartments. Instead, a semipermeable membrane incorporated into the simulated blood flow simulates organ-to-organ contact in a manner that is much more representative of real human organ systems.
It offers a method of identifying the pharmacokinetics of a test compound not just on a single organ, but on interconnected organ systems.
HuDMOP® At a Glance
HuDMOP ™ is a physiologically correct, simple, and affordable alternative to in vivo testing and single organ in vitro models. These are its main benefits:
✓Gain human-relevant, physiologically correct data in vitro
✓Understand compound movement in a simulated blood flow
✓Understand the metabolism and toxicity of a test compound
✓Develop pharmacokinetic and toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models
Applications of HuDMOP® Microphysiological Systems Testing
HuDMOP® is a flexible system. It can be adapted to meet any experimental design needs. It can be used to test the interactions of two, three, or four organ systems. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.
Commonly Integrated Organ Models
✓Lung (apical)-Liver-Lung (basolateral)