Microphysiological Systems Testing
HuDMOP® is a unique multi-organ microphysiological system developed by IonTox and our collaborators. This flexible system replicates interconnected organ systems using human tissue cultured in a mesoscale plate. It provides superior, human-relevant data about the systemic impacts of a compound without in vivo testing.
HuDMOP® is the next step from organ-on-a-chip systems. It’s a cost-effective alternative or precursor to animal studies. It obtains data that leads to a better understanding of systemic absorption, metabolism, and potential toxicity of a tested compound. The results of multi-organ microphysiological system testing are often more representative than animal models and can prevent costly failures.
HuDMOP® is the next step from organ-on-a-chip systems. It’s a cost-effective alternative or precursor to animal studies. It obtains data that leads to a better understanding of systemic absorption, metabolism, and potential toxicity of a tested compound. The results of multi-organ microphysiological system testing are often more representative than animal models and can prevent costly failures.
How HuDMOP® Works
HuDMOP® stands for Human Dynamic Multi-Organ Plate. This test uses cultured human tissues representative of specific organs that are connected to one another via a simulated blood system. Each organ compartment contains growth media optimal for that particular tissue or cell type.
There is no net exchange of fluid between the compartments. Instead, a semipermeable membrane incorporated into the simulated blood flow simulates organ-to-organ contact in a manner that is much more representative of real human organ systems.
It offers a method of identifying the pharmacokinetics of a test compound not just on a single organ, but on interconnected organ systems.
HuDMOP® At a Glance
HuDMOP ™ is a physiologically correct, simple, and affordable alternative to in vivo testing and single organ in vitro models. These are its main benefits:
✓Gain human-relevant, physiologically correct data in vitro
✓Understand compound movement in a simulated blood flow
✓Understand the metabolism and toxicity of a test compound
✓Develop pharmacokinetic and toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models
Applications of HuDMOP® Microphysiological Systems Testing
HuDMOP® is a flexible system. It can be adapted to meet any experimental design needs. It can be used to test the interactions of two, three, or four organ systems. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.
Commonly Integrated Organ Models
✓Intestine-Liver
✓Intestine-Liver-Kidney
✓Skin-Liver
✓Skin-Liver-Kidney
✓Lung-Liver-Kidney
✓Lung (apical)-Liver-Lung (basolateral)
There is no net exchange of fluid between the compartments. Instead, a semipermeable membrane incorporated into the simulated blood flow simulates organ-to-organ contact in a manner that is much more representative of real human organ systems.
It offers a method of identifying the pharmacokinetics of a test compound not just on a single organ, but on interconnected organ systems.
HuDMOP® At a Glance
HuDMOP ™ is a physiologically correct, simple, and affordable alternative to in vivo testing and single organ in vitro models. These are its main benefits:
✓Gain human-relevant, physiologically correct data in vitro
✓Understand compound movement in a simulated blood flow
✓Understand the metabolism and toxicity of a test compound
✓Develop pharmacokinetic and toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models
Applications of HuDMOP® Microphysiological Systems Testing
HuDMOP® is a flexible system. It can be adapted to meet any experimental design needs. It can be used to test the interactions of two, three, or four organ systems. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.
Commonly Integrated Organ Models
✓Intestine-Liver
✓Intestine-Liver-Kidney
✓Skin-Liver
✓Skin-Liver-Kidney
✓Lung-Liver-Kidney
✓Lung (apical)-Liver-Lung (basolateral)
Create Multiple Microphysiological Systems With One Platform
The HuDMOP® Microphysiological System is flexible to meet the experimental design needs of the client. The ability to study two, three or four organ systems is now possible. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.
About IonTox
Founded in 2014, IonTox is an innovative biomedical company specializing in in vitro testing. Our main focus is on advancing alternative toxicology research methods to help companies from a range of industries bring safe, effective products to market. We consult companies from a variety of industries, including pharmaceutical and cosmetics.
Speak to Our Scientists About Microphysiological Systems Testing
For more information on the HuDMOP® microphysiological system, book a 45-minute consultation with an IonTox scientist via our contact page.
Founded in 2014, IonTox is an innovative biomedical company specializing in in vitro testing. Our main focus is on advancing alternative toxicology research methods to help companies from a range of industries bring safe, effective products to market. We consult companies from a variety of industries, including pharmaceutical and cosmetics.
Speak to Our Scientists About Microphysiological Systems Testing
For more information on the HuDMOP® microphysiological system, book a 45-minute consultation with an IonTox scientist via our contact page.
HuDMOP® At A Glance
✓Gain human relevant physiologically correct data in vitro
✓Understand compound movement in a simulated blood flow
✓Understand metabolism and toxicity
✓Develop pharmacokinetic/ toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models
✓Understand compound movement in a simulated blood flow
✓Understand metabolism and toxicity
✓Develop pharmacokinetic/ toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models
Common Integrated Organ Models
✓Intestine-Liver
✓Intestine-Liver-Kidney
✓Skin-Liver
✓Skin-Liver-Kidney
✓Lung-Liver-Kidney
✓Lung (apical)-Liver-Lung (basolateral)
✓Intestine-Liver-Kidney
✓Skin-Liver
✓Skin-Liver-Kidney
✓Lung-Liver-Kidney
✓Lung (apical)-Liver-Lung (basolateral)