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Microphysiological Testing

Discover HuDMOP™


Microphysiological System Screens

Microphysiological Drug or Chemical Screening

HuDMOP™ is IONTOX’s Microphysiological System (MPS). HuDMOP™ uses human tissues representative of specific organs cultured in a mesoscale plate. Multiple organs represented by 2D or 3D models are connected to one another via a simulated blood system, and each organ compartment contains growth media optimal for that particular tissue or cell type. There is no net exchange of fluid between the compartments. Organ-to-organ contact is via a semipermeable membrane incorporated into the simulated blood flow.

In the last five years, IONTOX has worked with several collaborators to develop, test, and optimize the HuDMOP ™ System. This state-of-art system has addressed many of the issues that have plagued other platforms. HuDMOP ™ is physiologically correct, simple in construction, and affordable use.

Create Multiple Microphysiological Systems With One Platform

The HuDMOP™ Microphysiological System is flexible to meet the experimental design needs of the client. In fact, the ability to study two, three or four organ systems is now possible. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.

For more information on the HuDMOP™ microphysolgical system request to speak a scientist with via the contact tab in the upper right hand corner of your screen.

HuDMOP™ At A Glance

✓Gain human relevant physiologically correct data in vitro
✓Understand compound movement in a simulated blood flow
✓Understand metabolism and toxicity
✓Develop pharmacokinetic/ toxicokinetic parameters
✓Study the downstream effect of compounds on multiple organs
✓Develop PBPK models

Common Integrated Organ Models
✓Intestine-Liver
✓Intestine-Liver-Kidney
✓Skin-Liver
✓Skin-Liver-Kidney
✓Lung-Liver-Kidney
✓Lung (apical)-Liver-Lung (basolateral)