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in vitro services

In Vitro Testing Overview 

In Vitro Methods In The 21st Century

For decades, toxicological and ADME assessments of drugs and chemicals were performed on animals. However, because of ethical concerns and the increasing costs of bringing a drug to market, in vitro methodologies are now much more commonplace.

In recent years, these in vitro methods have been developed to be increasingly predictive of the human response, all while providing far more rapid turnaround times compared to in vivo studies. Regulatory agencies around the world are becoming much more accepting of in vitro data as a replacement for animal studies.

IONTOX’s world-class in vitro toxicology and ADME services help support your drug discovery program.  We offer cytotoxicity screens, organ specific toxicity assessments and 3D tissue models for OECD compliant irritation studies.  We also offer systemic toxicity assessments through our proprietary HuDMOP platform.

Available Screens

Cytotoxicity 

3D Tissue Models

  • Dermal Corrosion
  • Dermal Irritation
  • Ocular Irritation 

    Organ Specific Toxicity

    • Skin
    • Ocular
    • Thyroid 
    • Liver
    • Kidney
    • Lung
    • Intestinal

    ADME

    • Biliary Clearance 
    • Caco-2
    • Plasma Protein Binding 
    • Metabolic Stability 
    • CYP Inhibition
    • CYP Induction  

    Multiple Organ Models

    • Gut-Liver
    • Skin-Liver
    • Lung-liver
    • Lung-liver-lung
    • Lung-liver-Kindey

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