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ADME-PK

In vitro ADME and Pharmacokinetics

In Vitro ADME

For over 50 years, pharmacokinetics (PK) has been described using the 4-letter acronym ADME, or absorption, distribution, metabolism, and excretion.  As the cost of bringing a drug to market increases and the potential for marketed drug withdrawals due to unforeseen ADME issues climb, it is crucial to fully characterize your drug candidates as early as possible.  ADME/PK screening in the hit-to-lead and lead optimization phases can help reduce failure rates later on by offering accurate information on ADME, potential drug-drug interactions (DDIs) and potential unforeseen toxicities.

In vitro ADME Assays

As the cost of bringing a drug to market increases and the potential for marketed drug withdrawals due to unforeseen ADME issues climb, it is crucial to fully characterize your drug candidates as early as possible. The category of in vitro ADME includes a panel of in vitro assays that support companies seeking to characterize their compound with PK data. In vitro ADME assays in the hit-to-lead and lead optimization phases can help reduce failure rates later on by offering accurate information on ADME, potential drug-drug interactions (DDIs) and potential unforeseen toxicities.

IONTOX In Vitro ADME Assays

IONTOX provides the following in vitro ADME assays to meet your organization's research needs.

Added Benefit Of Working With IONTOX For In Vitro ADME Research

Along with providing a detailed final report for each study, IONTOX will suggest follow-up studies to further your organization’s research goals. Whether the company is seeking to achieve a successful regulatory submission, or to further pharmacokinetic knowledge around a specific compound, we can provide guidance on the best path forward.


Work With IONTOX

Click the button below and fill out the form on the following page to contact IONTOX about your in vitro ADME project