1)Increase the speed and accuracy of generating preclinical toxicity data
2)Understand the interaction between key organ systems
3)Obtain pharmacokinetic and Pharmacodynamic data sets
HuDMOP is IONTOX’s Microphysiological System (MPS). HuDMOP uses human tissues representative of specific organs cultured in a mesoscale plate. Multiple organs represented by 2D or 3D models are connected to one another via a simulated blood system, and each organ compartment contains growth media optimal for that particular tissue or cell type. There is NO net exchange of fluid between the compartments. Organ-to-organ contact is via a semipermeable membrane incorporated into the simulated blood flow.
In the last five years, IONTOX has worked with several collaborators to develop, test, and optimize the HuDMOP System. This state-of-art system has addressed many of the issues that have plagued other platforms. HuDMOP is physiologically correct, simple in construction, and affordable use.
The HuDMOP Microphysiological System is flexible to meet the experimental design needs of the client. In fact, the ability to study two, three or four organ systems is now possible. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.
Below is a list of the common Microphysiological System screens used by IONTOX clients:
Lung (apical)-Liver-Lung (basolateral)
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