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Microphysiological System

Microphysiological System

Microphysiological System Drug or Chemical Screening

1)Increase the speed and accuracy of generating preclinical toxicity data
2)Understand the interaction between key organ systems
3)Obtain pharmacokinetic and pharmacodynamic data sets

HuDMOP® is IONTOX’s microphysiological system (MPS). HuDMOP® stands for Human Dynamic Multiple Organ Plate and uses human tissues representative of specific organs cultured in a mesoscale plate. In the HuDMOP® microphysiological system, organs represented by 2D or 3D cell or tissue models are connected to one another via a simulated blood system. In the system each organ compartment contains growth media optimal for that particular tissue or cell type and there is NO net exchange of fluid between organ compartments. Organ-to-organ contact is via a semipermeable membrane incorporated into the simulated blood flow.

Over the last five years, IONTOX has worked with several collaborators to develop, test, and optimize the HuDMOP® system. This state-of-art system has addressed many of the issues that have plagued other platforms. HuDMOP® is physiologically correct, simple in construction, and affordable to use.

Microphysiological System Uses

The HuDMOP® microphysiological system is flexible to meet the experimental design needs of the client. In fact, the ability to study two, three or four organ systems is now possible. Cell or tissue models are well characterized and the data obtained can even be tailored to answer researchers’ questions.


Common HuDMOP® Microphysiological Screens

Below is a list of the common microphysiological system screens used by IONTOX clients:

Intestine-Liver
Intestine-Liver-Kidney
Skin-Liver
Skin-Liver-Kidney
Lung-Liver
Lung-Liver-Kidney
Lung (apical)-Liver-Lung (basolateral)

Learn More About Microphysiological System Screens

Contact IONTOX to learn more about Microphysiological System Screens

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