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Hepatotoxicity

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Hepatotoxicity Screen

When asking questions related to hepatotoxicity IONTOX client’s can select from a wide variety of standard tumor cell lines from multiple species, such as HepG2 cells (human) or H4IIE cells (Rat), that can provide important information on specific targets of toxicity, or be used to prioritize a large set of test compounds for toxicity relative to reference compounds in a screening environment. When a screening is performed in the context of exposure concentration relative to in vivo plasma concentrations reasonable extrapolations to animals or humans can be obtained.

Cell Models Available

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    HepG2 (Human)
    H4IIE
    Hepatocytes in Sandwich Culture (For understanding Biliary Clearance)

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